Basilica dei Santi Cosma e Damiano

The church of Santa Maria Antiqua, built in the 5th century, is the oldest Christian building in the Forum. The interior of the church is decorated with ancient Byzantine frescoes, dating from the time of Popes Martin I (649-655), John VII (705-707) and Zechariah (741-752). It contains the oldest representation in Rome of Santa Maria Regina, the Virgin Mary as Queen, dating from the second century.

The church of Santi Luca e Martina was founded in the 7th century, probably by Honorius I, who is also credited with the foundation of the neighbouring church of Saint Hadrian. The church was restored by Pope Alexander IV in 1256, and the patronage of Saint Luke (patron saint of painters) was added to the church by Sixtus V in 1588.

The church of Santa Maria della Neve was first mentioned in the 12th century. In 1607, the building was given to the University of Rigattieri, which rebuilt it at its own expense, in the Baroque style. After the French Revolution, the church was entrusted to the Confraternity of Santa Maria della Neve and its name was changed to its current name.