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The Sanctuary of Nostra Signora della Guardia was built between 1926 and 1931 by order of Don Luigi Orione on the site of the church of the Madonna delle Grazie in 1000, which was run by the Benedictines and later the Franciscans. In 1418, Bernardino of Siena, who gave his name to the village, preached in front of the church. In 1585, a four-sided "pillar" or tabernacle was built on the site of the original church, which was in an advanced state of decay. In the 17th century, a larger sanctuary was built around the "pillar". In 1662, the Franciscans were replaced by the Augustinians, until 1802, when they were suppressed by Napoleon.

The Sanctuary of Nostra Signora di Montallegro, built in the mid-sixteenth century, is a Marian sanctuary that commemorates an apparition of the Virgin Mary in 1557. The construction and management work was entrusted to the master Tommasino Lagomaggiore, an initial project with a single nave, with a marble facade much more varied than the present one. The current marble façade is the work of the architect Luigi Rovelli, and was solemnly inaugurated on 21 June 1896.

The church of San Francesco di Paola and the adjoining convent of the Ordine dei Minimi is a religious complex built between 1464 and 1467. In the 17th century, the religious complex received Baroque additions, probably during the restoration work carried out at the time of two disastrous earthquakes (1613 and 1638). After the Val di Noto earthquake in 1693, the restoration work on the church gave it a late Baroque (Sicilian Baroque) style like most of the buildings in the town. The temple was burnt down on 10 May 1908 and damaged by the Messina earthquake on 28 December of the same year.

The Sanctuary of San Vito began to be built around the 14th century, as a small chapel dedicated to St Vitus the Martyr. The temple was enriched with the proceeds of indulgences granted by Pope Innocent VIII in 1485. In 1526, the entire complex benefited from the munificence of Emperor Charles V of Habsburg. Raised to the rank of sacramental church in 1667 by Monsignor Giuseppe Cigala, Bishop of Mazara, for the assistance of pilgrims in danger of death, it was finally erected as a parish in 1854 by Vincenzo Ciccolo Rinaldi, before the new diocese, in the nascent town of San Vito Lo Capo.

The Santuario di Santa Caterina stands on the birthplace of Catherine of Siena (14th century). The sanctuary includes the Hall of the Saints (Camera della santa), the church Chiesa del Crocifisso (consecrated on 23 April 1623), the sacristy, and the oratories: Oratorio di Santa Caterina, Oratorio della Tintoria (built between 1466 and 1474), and Oratorio della Cucina.

The Sanctuary of Santa Maria del Canneto is a Baroque church that was built in the second half of the 17th century on a pre-existing sacred building dating from 1504. A first church had been built here in the 13th and 14th centuries and was destroyed in 1502 after the French siege. The interior of the present church is divided into three naves. The precious wooden coffered ceiling has a gilded icon of the Virgin Mary in the centre, while a large archway with floral motifs leads to the presbytery.

The Sanctuary of Santa Maria di Piazza is a Marian sanctuary that was built between 1515 and 1522 on the site of an earlier church dedicated to Our Lady, which had itself replaced a chapel dating from the Christian era. The architect of this Renaissance church was Antonio da Lonate (1456-1541).

The shrine of St. Therese of the Child Jesus is part of a convent of Discalced Carmelites who settled in the town in 1929. The shrine is dedicated to Therese of Lisieux. The church was built between 1931 and 1933, designed by the Milanese architect Ugo Zanchetta. The church became a parish church in 1964.

The Santuário do Bom Jesus do Monte is an important place of pilgrimage as well as a UNESCO World Heritage Site. A hermitage already existed here in the 14th century, and as pilgrims came in greater numbers, another was built here in 1494. At the beginning of the 16th century, in 1522, a third hermitage was built. In 1722 the idea of the present monument with the monumental staircase was born. However, work did not begin until 1784 and was completed in 1811.

Saraç Mosque, also known as Kukli Mehmet Bey Mosque, is a historic mosque in Prizren, very close to the historic centre. It is one of the oldest mosques in the city and in Kosovo.