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The church of Madonna dell'Orto was founded in the 14th century by the Humiliati order with a monastery. In 1377 a Gothic church was built with donations; the occasion was the transfer of a miraculous statue of the Madonna, which had been found in a nearby garden. The church itself was completed around 1400, but the facade was not finished until 1460-1464. After the expulsion of the Humiliati, the monastery passed to the Canons Regular of San Giorgio in Alga. After their dissolution in 1669, it was acquired by the Cistercian monks who remained there until the end of the Republic in 1797.

The church of the Madonna di Piè di Piazza was built in 1447, possibly to a design by Andrea Cavalcanti, known as Buggiano. It is characterised by a system of large arches that interrupt the high entablature on three sides and present the Serlian motif. Most of the original stone elements have disappeared; the pillars, cornices, corbels and friezes visible today are in fact the result of replacement restorations carried out by workers active in the 1920s and 1940s.

The church of the Madonnina dei Ronchi is an octagonal church that was built during the Counter-Reformation. In order to build this new place of worship, a pre-sixteenth-century oratory chapel along Corso Sempione, at the corner of today's Via dei Ronchi, was transformed into a real church. The church of the Madonnina dei Ronchi was designed by Francesco Maria Richini. This religious building is reminiscent of the church of San Giuseppe in Milan, also designed by Richini.

The Martorana or Santa Maria dell'Ammiraglio was built in the 12th century in the Arab-Norman style. Despite numerous restructuring and renovation, the Martorana is known for having incredibly well preserved 12th-century Byzantine mosaics. It is a UNESCO World Cultural Heritage site since 2015.

The Church of the Misericordia was built between 1883 and 1892. It is characterised by a poly-lobed central plan, with a domed roof, and two small rectangular chapels stand on either side of the single entrance. The interior is divided into five semicircular chapels; along the walls of the first chapel is the Stations of the Cross, while the next chapel contains two 19th-century altars made of gilded wood and painted in a light Renaissance style.

The church of the Pietà was built in its present form between 1745 and 1760 to a design by Giorgio Massari (1687-1766). However, the façade remained unfinished until the beginning of the 20th century: it was not until 1906 that the work was completed according to the original project, the only change being the upper ornamentation. The previous building, destroyed by the deterioration of time, was located on the right side of the present church.

The Sacra Famiglia church, built in 1971-1974, is the first religious building made entirely of reinforced concrete. The architect, Paolo Portoghesi, wanted to create a building that would express Christians concepts such as unity and centrality of the divine through the choice of curved shapes. The different colours of the windows symbolize the dialogue between the human nature and the divine nature. The tubular structures can be assimilated to lit flames that orient visitors upwards, where the circular openings invite direct contact with God.

The church of Santissima Annunziata a Fonseca was founded in 1620 by Cardinal Decio Carafa, then Archbishop of Naples, on land belonging to the noble Fonseca family, purchased in 1616. Enlarged in the 19th century, it was severely damaged by the bombings of the Second World War. In 2003, the church was renamed Santissima Annunziata and dedicated to Saint Jeanne Antida Thouret (1765-1826), a French saint who worked for the patients of the Incurables Hospital in Naples.

The construction of the Annunziata dei Catalani began in the second half of the 11th century (apse, transept, dome) and was completed at the beginning of the following century (façade and porches) after an earthquake. It seems that the builders of the church incorporated elements (columns) from an ancient temple of Neptune into its construction. The church has a typical plan of late Norman architecture in Sicily.

The church of the Santissima Annunziata was probably built around 1511 and was damaged in 1964 when the adjacent building collapsed. The façade has a large rose window, which surmounts the portal carved with a relief of the "Annunciation". The portal was dismantled and reassembled at a lower level in the second half of the 19th century when the street level was lowered, which also led to the creation of two internal stairways. The bell tower, which is not very high, flanks the façade and has a mullioned window.